Clemastine attenuates AD-like pathology in an AD model mouse via enhancing mTOR-mediated autophagy

Alzheimer's disease (AD) is a neurodegenerative disorder with limited available drugs for treatment. Enhancing autophagy attenuates AD pathology in various model mice. Thus, development of potential which enhance may bring beneficial effects therapy. In the present study, we show clemastine, first-generation histamine H1R antagonist and being originally marketed treatment allergic rhinitis, ameliorates pathogenesis APP/PS1 transgenic Chronic clemastine orally reduced amyloid-? (A?) load, neuroinflammation cognitive deficits Clemastine decreases A? generation via reducing levels BACE1, CTFs APP. Mechanistically, enhances concomitant suppression mTOR signaling. Therefore, propose that enhancing mTOR-mediated autophagy.